Amidochromenes for Promising Antileishmanial Activity
نویسندگان
چکیده
منابع مشابه
N-cinnamoylated aminoquinolines as promising antileishmanial agents.
A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 μM) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 μM) of Leishmania infantum. Both...
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Leishmaniasis is a neglected tropical disease caused by protozoan parasites belonging to the genus Leishmania. Currently, the drugs available for treatment of this disease present high toxicity, along with development of parasite resistance. In order to overcome these problems, efforts have been made to search for new and more effective leishmanicidal drugs. The aim of this study was to synthes...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2017
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1701200919